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KMID : 0359720140320020098
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Journal of the Korean Neurological Association
2014 Volume.32 No. 2 p.98 ~ p.102
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Logopenic Progressive Aphasia Revealing Positive Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease
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Kim Hyung-Jun
Kim Tae-Eun
Kim Sae-Ro-Mi
Chai Won-Seok
Park Sun-Ah
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Abstract
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Primary progressive aphasia (PPA) is classified into agrammatic, semantic, and logopenic variants, but differential diagnosis is often challenging. There is accumulating evidence that the neuropathology of logopenic PPA is distinct from
that of the other types. We report herein a woman with logopenic PPA who was diagnosed by clinical, neuropsychological,
and radiologic data during 2 years of follow-up. Interestingly, her cerebrospinal fluid biomarkers were found to be similar to those found in Alzheimer’s disease, with a decreased concentration of Aβ42 and an increased concentration of pTau181(tTau).
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KEYWORD
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Biomarker, Cerebrospinal fluid, Logopenic aphasia
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